Tofacitinib: A novel oral treatment for rheumatoid arthritis

Researchers report on a revolutionary new procedure that uses 3-D printing and the body’s stem cells to regenerate knee meniscus, a tissue lining that acts as a natural cushion between the femur and tibia. People with damaged menisci develop arthritis and are forced to limit their activity. The procedure, published online Dec. 10 in the journal Science Translational Medicine, has proved successful in sheep at Cornell University six months after surgery, though the researchers will monitor the…

For 48-year-old Sachi Pathak, life was never pain-free. A sports enthusiast, Sachi was always ahead in participating in all gymnastic activities in her school. One day while forming a pyramid (a gymnastic formation) she fell on her knees. Her knees became stiff and her movement became limited. She was rushed to the nearest hospital and over a series of diagnostic tests it was found that she suffered from rheumatoid arthritis.  In Sachi’s case, RA had affected both her knees and hip joints…

Indian drugmaker Cadila Healthcare Ltd said on Tuesday it launched in India the first biosimilar version of the anti-inflammatory medicine adalimumab, the world's top-selling drug, at a fifth of its U.S. price. Adalimumab was approved globally in 2002 and has been the most preferred drug for patients suffering from auto immune disorders.  The drug's branded version is sold under the name Humira by U.S. firm AbbVie Inc, and costs $1,000 for a vial in the United States. Humira…

Find out this and more from Dr Shital Raval  1. Can excess weight cause osteoarthritis? Recent medical opinion points to excess weight as a cause for osteoarthritis. It is also known that obesity makes the symptoms worse in patients with existing osteoarthritis. This is because obesity tends to decrease mobility and puts stress on the back, hips, knees and feet, all the body parts that are commonly affected by osteoarthritis. Over time this stress can cause the…

In a new study recently presented at the American College of Rheumatology Annual Scientific Meeting in Boston, MA, researchers have linked antibiotic use in children to increased risk of juvenile idiopathic arthritis or juvenile Rheumatoid Arthritis. The researchers found that children exposed to antibacterial antibiotics - not antifungals or antivirals - were at higher risk of developing JIA than those who had not been exposed to these antibiotics. This risk was higher for children who had…

In June 2014, the U.S. Food and Drug Administration (FDA) approved two generic versions of celecoxib (Celebrex). Developed by Pfizer, celexocib is used to treat rheumatoid arthritis, osteoarthritis, as well as other conditions. Approval was granted to Mylan Pharmaceuticals, Inc. to market 50 mg celecoxib capsules, while Teva Pharmaceutical Industries received approval to market the drug in the following doses: 50 mg, 100 mg, 200 mg, and 400 mg, according to a bulletin from the FDA. Teva was…

Inflammation has been linked to a slew of diseases – from allergies to cancer, heart trouble, bowel problems and diabetes. What is it and how can we protect ourselves. - By paediatrician and family practitioner Dr Gita Mathai. What is inflammation? The word is derived from the Latin “inflammo” meaning ignite or set alight. It conjures up visions of fire, and it is the body’s response to an injury, like a broken bone, a scrape in the skin or an infection by an organism (…

Exercise has been shown to transiently suppress inflammation in an animal model of rheumatic disease, bolstering evidence to support the theory that regular physical activity is beneficial for patients with the disease. “Exercise can be a very potent therapeutic intervention to control inflammatory diseases, but unfortunately today it is underutilized in clinical practice,” said study author Dr. Nicholas Young from The Ohio State University Wexner Medical Center, Columbus, Ohio, US. “[In our…

Researchers find 6,000 steps per day is the “magic” number for preventing activity limitations in people with knee osteoarthritis (OA), according to a new study published recently online in Arthritis Care & Research. If you have not been doing much walking, start with 3000 steps and then move up to 6000 steps per day http://www.arthritistoday.org/news/walking-protects-against-limitations-348.php

Tofacitinib (Xeljanz®) is the first of a unique class of oral kinase inhibitors to be FDA approved for the treatment of rheumatoid arthritis (RA). Tofacitinib is a selective inhibitor of Janus kinase (JAK) enzymes. these enzymes mediate signaling for several important cytokines that cause the inflammation in Rheumatoid Arthritic patients.  http://www.hopkinsarthritis.org/arthritis-news/tofacitinib-fda-approved-oral-biologic-for-rheumatoid-arthritis/